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doi:10.1371/journal.pone.0040365 Philippova M, Joshi MB, Pfaff D, Kyriakakis E, Maslova K, Erne P, Resink TJ (2012) T-cadherin attenuates insulin-dependent signalling, eNOS activation, and angiogenesis in vascular endothelial cells

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This is achieved at the lower dose level and not at the maximum theoretical dose level (20 mg) to incorporate changes required if In-vivo release is much slower than In-vitro release