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One thing that does not get enough attention is that different GLP-1 receptor agonists cross the bloodbrain barrier at widely varying rates, and these differences could well explain why trial results have been so mixed

No large-scale randomised controlled trials have evaluated this combination, and current prescribing guidance from the MHRA, NICE, or EMA does not specifically address concurrent use

doi: 10.1093/humrep/den109

Any degradation introduces a variable that can compromise your data