In the matched non-nave cohorts, 14% of tirzepatide ( N = 792) and 13% of semaglutide initiators ( N = 738) had baseline and follow-up HbA1c data
Testosterones cardiac reputation, for years the big fear, mostly held up to scrutiny: in a trial of more than 5,000 men at high cardiovascular risk, TRT did not cause more heart attacks than placebo (Lincoff, New England Journal of Medicine, 2023)
Weight Loss Q&A Am I a good candidate for GLP-1 treatment
The better choice depends on your goals, health history, and access to medical guidance
This extended duration is due to semaglutide's unique pharmacokinetic properties, which allow for once-weekly dosing but also mean the medication persists in your system considerably longer than daily medications
Through activation of the GLP-1 receptor, it enhances insulin secretion, suppresses glucagon release, delays gastric emptying, and reduces food intake via central appetite regulation