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If positive, it would establish tirzepatide as a life-extending medication, not merely a weight management tool
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Furthermore, in fibroblasts, DNA synthesis and cell proliferation in response to IGF-I decrease with elderly[359]
First, although we identified significant alterations in pathways such as fatty acid -oxidation and PPAR signaling, we lacked direct functional validation through experiments such as mitochondrial respiration assays, gene expression analysis of key regulators (e.g., PPAR target genes), or isotopic tracing of fatty acid oxidation