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The titration schedule looks like this: 2.5mg for weeks 1 through 4, then 5mg for weeks 5 through 8, then 7.5mg for weeks 9 through 12, then 10mg for weeks 13 through 16, and potentially 12.5mg and 15mg after that

Although a fairly large proportion of patients have reported a number of side effects, particularly at the gastrointestinal level (nausea, vomiting, diarrhoea), these side effects tend to diminish over time and adherence to treatment remains high, with about 5% of patients discontinuing treatment due to side effects

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This relationship is seen consistently in the leaves of several amaranth species (Sarker et al., 2020b