however, human studies are sparse
Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers
That is not negligible when you are simultaneously introducing a new GLP-1 agonist
The most common effects are: Nausea, particularly in the first few weeks after a dose increase Vomiting (less common) Diarrhea or constipation Reduced appetite (this is the desired effect, but it can feel unfamiliar) Most side effects are temporary and improve as your body adjusts
In fact, doctors warn that nightly use can cause grogginess, memory issues, and even increase your risk for dementia over time due to how Benadryl affects brain chemicals like acetylcholine
Key Takeaway It Happens More Often Than You Think