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The FDA's shortage-based enforcement discretion periods for both semaglutide and tirzepatide compounding have ended, and the regulatory environment for compounded GLP-1 products continues to evolve
GLP-1 receptor agonists mimic this hormone, binding to GLP-1 receptors throughout the body, particularly in the pancreas, brain, and gastrointestinal tract
Complementing its insulinotropic effects, GLP-1 also suppresses the release of glucagon, slows gastric emptying and intestinal motility, and induces feelings of satiety 5
Prescribers should ensure that GLP-1 agonists are prescribed and administered properly, and that their patients receive adequate education and counseling regarding their potential effects
Maintaining weight loss after discontinuation requires sustained lifestyle changes including dietary modifications and regular physical activity
The ACC also supports the use of GLP-1R agonists for cardiovascular risk reduction in patients with T2DM and multiple ASCVD risk factors, independent of glucose control or background antihyperglycemic therapy [122]
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