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In turn, the plasticiser BPA was shown to affect epigenetic regulators such as histone deacetylase SIRT1, and the histone methyltransferase SET8 in PCa cells [291]

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The cardiovascular outcomes trials that enrolled tens of thousands of patients with type 2 diabetesincluding LEADER (liraglutide), SUSTAIN-6 (semaglutide), REWIND (dulaglutide), and EXSCEL (exenatide ER)found no significant increase in overall cancer incidence compared to placebo over follow-up periods ranging from approximately two to five years