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Preferred techniques include spinal anaesthesia for orthopaedic procedures, interscalene blocks for upper extremity surgery, and femoral/sciatic blocks for lower extremity procedures [67]

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This includes enlarged hands, feet, jaw, and internal organ enlargement (for example: heart, liver)

Investigators have described this pattern as a "broad reset" of pathways associated with cellular aging language that, while evocative, remains pre-clinical and has not been translated into validated human therapeutic claims

This strategy achieved rapid disease stabilization and successful bridging to curative HSCT(49)