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We provide evidence that the expression of key enzymes in SAA metabolism is under transcriptional control by HNF4

A 2025 study in Aging Cell confirmed these findings in both normal epithelial and fibroblast cell lines, identifying hTERT upregulation as the primary mechanism in normal cells (4)

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Larson SD, Jackson LN, Riall TS, Uchida T, Thomas RP, Qiu S, Evers BM

In your 60s and beyond: Its about cellular resilience and healthy aging

Moreover, telomerase reverse transcriptase (TERT) promoter mutations, strongly associated with smoking, have been implicated in hepatocarcinogenesis and tumor progression [4143]