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The incidence of severe gastrointestinal adverse events leading to treatment discontinuation was higher with tirzepatide compared to some comparators but remained within acceptable ranges for most patients

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12,26 Furthermore, the formation of NAPQI adducts contributes to oxidative stress, mitochondrial dysfunction, disrupted Ca 2+ homeostasis, necrotic cell death, centrilobular necrosis, and eventual liver failure (Figs

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