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The development of novel therapeutics to address such complex tissue damage is therefore of high medical importance

The preclinical safety information for Wegovy adds: In developmental toxicity studies in rabbits and cynomolgus monkeys, increased pregnancy loss and slightly increased incidence of foetal abnormalities were observed at clinically relevant exposures. While the company is now carrying out trials to explore whether such drugs are safe for pregnant women, at present it advises that semaglutide should not be used during pregnancy as it is not known if it may affect an unborn child

However, improved glucose control, regular screenings, and comprehensive care have helped reduce some complication rates

This flexibility represents a significant advantage for patients, as it allows them to integrate their weekly injection into their routine without the constraints of fasting or coordinating with mealtimes

doi: 10.1210/jc.2017-02006 14 NakamoriHIidaKHashitaniH