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It is being investigated for its potential in treating neurodegenerative diseases and cognitive impairment

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In summary, the results demonstrate that Dihexa is a metabolically stable and BBB-permeable AngIV analog that effectively reverses scopolamine-induced cognitive deficits and improves spatial learning in aged rats

In preclinical cell culture assays measuring dendritic arborization and synaptic outgrowth, Dihexa demonstrated neurotrophic activity estimated to be up to seven orders of magnitude 1,000,000 times more potent than Brain-Derived Neurotrophic Factor (BDNF) on a molar basis

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References (For Scientific Context) Benoist CC et al., , 2014 Journal of Pharmacology and Experimental Therapeutics Wright JW et al., , 2015 Journal of Alzheimers Disease Sun X et al., , 2021 Brain Sciences Reviews There are no reviews yet