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In addition, insulin administration is known to result in increased GST gene expression through the PI3K/AKT/mTOR pathway and reduced intracellular oxidative stress, while glucagon decreases such gene expression
Protein damage tryptophan fluorescence (decrease in OD)
The experiment was divided into two parts: Part 1, in which they were randomly divided into four groups: the WT group, the APP/PS1 group, the APP/PS1+ Dihexa (1.44 mg/kg) group, and the APP/PS1+ Dihexa (2.88 mg/kg) group, and Part 2, in which mice were divided into three groups: the APP/PS1 group, the Dihexa (2.88 mg/kg) group, and the Dihexa (2.88 mg/kg) + wortmannin (0.5 mg/kg) group
systemic = whole-body tissue effects)
Research into Extracellular Matrix Dynamics Epithalon has been explored for its possible impact on extracellular matrix (ECM) proteins, such as MMP2, which are associated with tissue remodeling