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Retatrutide Dosage in Clinical Trials The primary source of dosage data for retatrutide comes from the Phase 2 clinical trial published in the New England Journal of Medicine (Jastreboff et al., 2023)

George Choose from physician-guided semaglutide and tirzepatide treatment options, including compounded medication when clinically appropriate and FDA-approved brands such as Wegovy and Zepbound

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Most patients can safely continue GLP-1 medications before colonoscopy with appropriate precautions, including a 24-hour liquid-only diet before the procedure

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TRIUMPH-4, the first completed Phase 3 trial, showed 28.7% average body weight loss at 68 weeks on retatrutide 12mg versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)