Limited data suggests semaglutide and tirzepatide transfer into breast milk at low levels, though clinical significance remains unclear
Qian, Y., Feldman, E., Pennathur, S., Kretzler, M., & Brosius, F
But they can be (and often are) prescribed off-label for that purpose, which is why theyre included in the table below
Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained increasing popularity for managing both type 2 diabetes mellitus and obesity
These drugs havent been directly compared in clinical trials
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells