2-deoxy-d-glucose ameliorates PKD progression
Systemic and topical administration work through different pathways, potentially complementing each other
Our skin constantly sheds its top layer of cells and replaces them with new ones (clever, isnt it!)
Based on several studies, it appears that GLP-1 RAs are safe and effective regardless of renal function status
Important Distinction: Unlike minoxidil which directly stimulates hair growth, spironolactone works by blocking the hormonal cause of hair loss
Dermatologic Common (1% to 10%): Hair loss, rash, urticaria Postmarketing reports : Alopecia, angioedema, rash, urticaria Hair loss was reported in up to 5.8% of treated patients vs 1% placebo, with higher incidence associated with greater weight loss (20% or more)