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Ficlatuzimab is currently the only biological therapy undergoing trial that targets the c-MET/HGF axis in HNSCC

doi: 10.1016/j.ntt.2021.106984 16 Albiglutide EMA product information (2023)

doi: 10.1245/s10434-020-08486-7 16 HogdallDLewinskaMAndersenJB

MAT1 KO hepatocytes can also be detected with reduced methylation/CYP2E1 ratio, reduced mitochondrial membrane potential, increased ROS content, and are sensitive to ethanol and TNF--induced mitochondrial dysfunction

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