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GLP-1s and Depression: Research Gaps Some of the uncertainty surrounding how GLP-1s influence mental health stems from early clinical trials

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According to other recent analyses, tirzepatide, retatrutide, and survodutide all significantly reduce liver fat without showing signs of worsening liver fibrosis markers [131]

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9 One meta-analysis synthesizing on the order of a dozen RCTs and several hundred participants found consistent improvement in HOMA-IR and anthropometric measures with GLP-1 receptor agonists relative to controls