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Batterham, M.B., B.S., Ph.D., Salvatore Calanna, Ph.D., Melanie Davies, M.D., Luc F

Patients who require insulin should be taught to consume a 15-g carbohydrate snack or a snack of complex carbohydrates with protein before engaging in moderate exercise

A case study exploring the efficacy of exenatide therapy in a 59-year-old NAFLD patient, reported a 73% reduction in hepatic fat content and significant improvements in liver enzymes 44 weeks post-treatment [20]

Its approval was preceded by the outcomes of five phase III trials, which are summarized in Tables 1 and 2, each of which compare tirzepatide at 5 mg, 10 mg, and 15 mg to other medications comparing similar clinical endpoints

[15] [16] In the brain, GLP-1 receptor activation has been linked with neurotrophic effects including neurogenesis [17] [18] and neuroprotective effects including reduced necrotic [19] and apoptotic [20] [19] signaling, cell death, [21] [22] and dysfunctions

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