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Factors such as stress, sodium intake, hormonal changes, poor sleep, travel, and exercise can all cause temporary water retention

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This partnership dramatically expanded access for patients in rural and underserved areas, and approximately 35% of Zepbound prescriptions in Q2 2025 were cash-pay , bypassing traditional pharmacy benefit manager gatekeeping entirely

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The overall physical and mental state should be assessed to ensure the combination does not create an undue burden