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In this issue of the JCI, Gaykema et al

Exendin-4 reverses biochemical and functional alterations in the bloodbrain and bloodCSF barriers in diabetic rats

GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning they promote insulin release only when blood glucose levels are elevated

But based on what I am seeing clinically and what the latest research is showing, there are actually five distinct pathways

It's not currently funded by Pharmac and runs about $500 per month for the weekly injections

It makes your stomach empty more slowly and helps reduce your appetite