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This led us to investigate the evidence for their use, and whether there are any other hidden gems in the literature that can help us care for patients who present with these syndromes

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Red blood cell metabolism in rhesus macaques and humans: Comparative biology of blood storage

5), where M (n)+ is usually a transition metal ion: Trace (nM) levels of cellular and circulating active transition metal ions seem enough for the catalysis of a slow Fenton reaction , at the physiological levels of H 2 O 2 (0.1-1.0 M) (Chance et al., 1979)

In a retrospective cohort study including 7,044 patients with T2D, obesity (BMI 27 kg/m 2 ) and HFpEF, combination therapy with an SGLT2i and GLP-1 RA showed a lower risk of HF exacerbation, all-cause emergency department visits and new-onset kidney injury compared with patients only receiving SGLT2i

These include the clearance of potentially detrimental metabolites and protein fragments, such as soluble A, from the brain [14], influencing tau protein dynamics [8], supporting the function of the blood-brain barrier (BBB) [15], maintaining synaptic integrity [16], consolidating memory [17], modulating glial activation [18], and regulating neuroinflammation [19]