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Furthermore, insulin therapy is often associated with undesirable weight gain, which may worsen insulin resistance, does not address other pathophysiological abnormalities, such as alpha cell dysfunction, and does not wholly protect individuals from an increased risk of cardiovascular disease or other complications

doi: 10.1016/j.ccell.2014.11.014 159 PattonEEMuellerKLAdamsDJAnandasabapathyNAplinAEBertolottoCet al

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