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Tregs transfer cAMP to effector T cells with subsequent inhibition of NFAT (Nuclear factor of activated T-cells) and IL-2 (Interleukin-2) transcription and with subsequent cellular apoptosis ( The pivotal action of Tregs in autoimmune diseases, such as T1D (Type 1 diabetes), is well established

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They may be removed in the following circumstances: To exclude cancer If a naevus is a nuisance: perhaps irritated by clothing, comb or razor Cosmetic reasons: the mole is unsightly

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