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Ethics declarations Ethics approval This study did not require ethics approval as it did not involve any human participants or animal subjects

The three mice models were SAMP-1 female mice with accelerated aging and wild rats SAMR-1 and SHR (both female mice)

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NK Cell Cytotoxicity Impairment Natural Killer cells provide first-line immune surveillance without prior antigen sensitisation, making their function critical in immune defence against diabetes

treat and monitor patient according to standard of care

IL-1R, IL-1, IL-6R, IL-6 a , IL-2, IL-10, IL-15, IL-17, IL-17R, IL-18, IL-23, interleukin (IL)-1 receptor, -1 beta, -6 receptor, -6 antibody, -2, -10, -15, -17, -17 receptor, -18, -23, respectively