(79) showed that promoting CB proliferation and SCFA production repairs the colonic mucosal barrier in DSS-induced mice by upregulating tight-junction proteins and increasing goblet cell numbers, dependent on CB -mediated amino acid and 2-oxocarboxylic acid metabolism
The anecdata seem to indicate that the mode of delivery, that is whether or not systemic or local, doesn't seem to matter that much

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Hormone Research 2001 Comparative studies of LH and hCG reveal distinct early-signaling profiles at the shared LH/CG receptor despite similar testosterone output
Zdzieblik, D., et al