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It remains unclear whether postoperative administration of glucagon-like peptide-1 analogues can promote additional benefits

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Acta 1830 , 31653172 (2013)

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Why it matters for weight loss: Poor insulin sensitivity is one of the biggest obstacles to fat loss

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However, when it mutates, IDH converts -KG to 2-hydroxyglutaric acid (2-HG) and competitively inhibits -KG-dependent DNA and histone demethylases (Xu et al., 2011), leading to a hypermethylation phenotype and may alter the differentiation of cancer stem cells (Yang et al., 2012

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