The abnormal function of these neurotransmitters is associated with several neurological diseases, such as ASD [146, 147]
The presence of intramolecular hydrogen bonds in the acid form causes it to be almost undissolved in water, whereas the inclusion of eight water-friendly groups in the dianion configuration provides some water solubility at neutral pH
As kidney function deteriorates, these toxins accumulate in the blood, causing many deleterious effects on body tissues and organs, thereby contributing to kidney damage and related complications such as cardiovascular disease and neurological disorders (Krukowski et al., 2023
Although several KD variants are available to increase adherence, additional modifications are still needed and should be specifically designed for distinct diseases to increase both efficacy and tolerability, while facilitating dynamic adjustment to minimize the short- and long-term adverse effects
Front Nutr 7:143 Zhang J, Saad R, Taylor EW, Rayman MP (2020) Selenium and selenoproteins in viral infection with potential relevance to COVID-19
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