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This is not unique to Retatrutide and applies to any significant weight loss intervention, but it is worth factoring into a long-term safety plan

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In addition, some studies on recently marketed GLP-1 RAs such as dulaglutide (AWARD studies), albiglutide (HARMONY studies), and lixisenatide (GetGoal studies) included cardiovascular parameters as a part of their non-primary endpoints (Table 2)

The most common side effects include nausea, upset stomach, constipation, fatigue, and headaches, which typically resolve with time