These are the glue that keeps the gut lining and vascular barriers intact, which is why it is often cited in discussions regarding leaky gut and systemic inflammation
However, a significant decrease in cell viability was observed for the solutions with pH lower than 2.5
This bidirectional effect, scientists call it buffering , is probably the key to its protective profile
Biochem Mol Biol Int 43:197205 Nielsen SF, Thastrup O, Pedersen R, Olsen CE, Christensen SB (1995) Structure-activity relationships of analogues of thapsigargin modified at O-11 and O-12
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