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The injectable form has been used for years

120 It has been demonstrated that genetic ablation of GIPR and GLP-1R either individually or at the same time in mice results in impaired insulin secretion confirming that both GIP and GLP-1 mediate the incretin effect

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These adaptations persist even after weight loss stabilizes, creating a biological drive to return to the previous weight set point

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Patients need guidance about eating small frequent meals, ensuring adequate protein, staying hydrated, taking vitamins