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Choose a time of dayoften first thing in the morning on an empty stomachand stick to it

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In summary, for the reasons discussed we are maintaining our estimate for the hours associated with recordkeeping at 5 and our estimate of hours associated with reporting at 15, which equals 20 hours of annual burden per hospital and 60,760 hours of estimated annual burden across all 3,038 hospitals

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10.1016/j.cell.2006.02.008 26 CsiszrJ.HorvthE.VryZ.Gall.BelaK.BrunnerS.et al

Uniquely, it had a time period at the end of the study where study medication was discontinued for 12 weeks, then reassessed to see if the treatment effects persisted