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They target the part of the brain that regulates appetite by mimicking the GLP-1 hormone

Notably, the hyperglycemic and high-AGE microenvironment within the DW vasculature and surrounding tissue actively reinforces and sustains the pro-inflammatory M1 macrophage phenotype through multiple interconnected mechanisms (Yu et al., 2025)

Ozempic affects the hunger control centre of the brain to suppress appetite and promote satiety

However, the safety and efficacy of such combinations require careful evaluation

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