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SELECT (N=17,604, NEJM 2023): 20% cardiovascular risk reduction sustained over 4 years

Inhibition of the EMT by sulforaphane in thyroid cancer cells has been associated with upregulation of an epithelial marker, E-cadherin, and downregulation of a transcription factor (SNAI2), a filament protein (vimentin), and various enzymes (matrix metalloprotein [MMP]-2 and MMP-9) known to contribute to EMT and promote migration (32)

The inactive form is considered a precursor as it gets converted into an active peptide GLP-1 (7-37) by cleaving a single arginine residue (Fig

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