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When shots make sense (and when they don't) Injections are the right call in specific situations: confirmed severe deficiency, pernicious anemia (where intrinsic factor is absent), or documented malabsorption that has failed to respond to oral supplementation

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Note that while elevated homocysteine is associated with an increased risk of Alzheimer's disease, systematic reviews of clinical trials comparing vitamin B12 supplementation to placebo groups have not shown a significant effect in preventing or slowing Alzheimer's disease or cognitive decline

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Targets 129 MorelloM.LandelV.LacassagneE.BarangerK.AnnweilerC.FeronF.et al (2018)