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Mitochondrion , Elsevier 16 , 717 9 Sundaresan, B., Shirafkan, F., Ripperger, K

Note, though, that the study analysis is not over, and the authors stated that they are trying to identify subgroups and describe phenotypical and/or biochemical characteristics

In practice with GHK-Cu: The copper dose delivered via typical topical or therapeutic administration is modest Short-term use has not been prominently associated with clinically significant zinc depletion Long-term or high-dose use warrants monitoring in patients where zinc balance is clinically important Patients with known zinc deficiency or on zinc-replacement should be monitored more closely A reasonable clinical approach: monitor copper and zinc status in patients on chronic GHK-Cu, particularly in symptomatic or long-duration protocols

This is a pretty common phenomenon known as dysgeusia, according to a research review

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And hope that someday, proper trials will finally answer the questions that decades of animal research have raised.