Pharmacokinetic optimization, vascular and stromal modulation, TME-responsive activation, immune intervention and imaging guidance are most useful when they are matched to dominant TME phenotypes and supported by measurable readouts
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Reestablishing the cellular metabolic homeostasis in inflammatory diseases as well as SARS-CoV-2 infection and COVID-19 disease especially in the lungs and cardiovascular system, could become paramount to balance altered innate and adaptive immunity and cell function and reduce morbimortality (333335)
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Recovery-focused peptides may show effects within weeks, while longevity-oriented use is a longer game
Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis