The more substantial weight reductions of 10-15% of body weight have been observed with higher-dose injectable semaglutide (2.4 mg) used specifically for obesity treatment, not with the Rybelsus formulation
Additionally, this drug led to improvements in cardiometabolic markers, such as blood pressure and cholesterol levels
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Tirzepatide is a dual GLP-1/GIP receptor agonist, meaning it activates two complementary pathways that regulate appetite, blood sugar, and energy expenditure more comprehensively than semaglutide alone
Conclusions To summarize, this secondary analysis of a randomized clinical trial examined changes in site-specific BMD during diet-induced weight loss followed by a 1-year intervention with liraglutide (3.0 mg/day), exercise, or their combination, compared to placebo
