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When exposed to Ex-4, cell cycle analysis revealed an increase of cells in S (synthesis)-Phase [15, 16] and proliferation related markers ( cyclin D3 , cyclin-dependent kinase 4 ( CDK4 ), c-Myc and c-fos ) increased, while cell cycle inhibitors ( p21Cip1 and p27Kip1 ) were downregulated [16]

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amino acid also includes stereoisomers and modifications of naturally occurring protein amino acids, non-protein amino acids, post- translationally modified amino acids, enzymatically synthesized amino acids, derivatized amino acids, constructs or structures designed to mimic amino acids, and the like

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