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In line with this, p53 modulators have been investigated as potential senolytic agents

This LASSS-HGF strategy could be adaptable to aging 32,41,42,68,69,70 and several disorders and diseases that show the generation and accumulation of nitrated HGF and particular nitrated proteins at specific sites, including cardiovascular damage 71,72 , chronic obstructive pulmonary disease (COPD) 73 , colon and lung cancer 74,75,76 , Alzheimers and Parkinsons diseases 44 46 ,77,78

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It is present in the cytosol and organelles

NAC treatment increased extracellular total antioxidant power and total thiol molecules and enhanced intracellular GSH and patients outcome (106)