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Side effects of B12 supplementation Vitamin B12 is a water-soluble vitamin, which means excess amounts are excreted through the urine

Rett syndrome, caused by MECP2 gene mutations, disrupts GABAergic interneuron development, lowering GABA concentrations in the hippocampus and prefrontal cortex, leading to developmental regression, such as loss of language and motor skills, and stereotypic hand movements like hand-wringing (77)

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More critically, the dependence of cardiomyocytes on mitochondria is more pronounced in ischemia and reperfusion injury due to the extremely high demand for energy supply in the heart [58]

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