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Se debe extremar la precaucin al tratar a estos pacientes con semaglutida (ver seccin Farmacocintica)

Moreover, a minor proportion of this agent can be metabolized within the liver by the cytochrome P450 enzymes (primarily by CYP2E1) to NAPQI, which is detoxified by conjugation and excreted in the glutathione or NAC forms ( Figure 2 )

Nocurrent evidence does not support semaglutide use during breastfeeding because animal studies show the drug enters breast milk and no human lactation data exists

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