If weight management is your primary goal, a different medication called Contrave (naltrexone + bupropion) is actually FDA-approved for that purpose when combined with lifestyle changes
Separate-vial workflow Staggered Co-Titration - Two Vials, Two Schedules Community protocols run retatrutide alone for 8 weeks before adding cagrilintide at the lowest dose, then step both up slowly across the next 16 weeks
Other studies have reported that a reduction in hippocampal neurogenesis leads to an increase in anxiety symptoms and the onset of depression (Hanson et al., 2011
Some people may also discuss other GLP-1-based or incretin-based medicines when cost, supply, or tolerability becomes a concern
doi: 10.1016/j.trsl.2015.08.005
Long-term treatment planning is an important conversation to have with a healthcare provider before starting therapy