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Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials

It has a neuroendocrine pathway independent of the GLP-1 receptors, working by stimulating melanocortin-4 receptors (MC4R) to reduce hunger and increase basal metabolic rate

Special Note (Zepbound & Birth Control): Tirzepatide can make oral contraceptives less effective

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The tablet must be swallowed whole without crushing or chewing

The table includes mean weight-loss percentage, approximate absolute weight loss (pounds), trial duration and the trial name