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doi: 10.1158/0008-5472.CAN-13-1865 149 BullmanSPedamalluCSSicinskaEClancyTEZhangXCaiDet al

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Vitamin D is also critical to male sexual function, as well as bone and muscle health, immune function, and mental health

However, against this hypothesis of a primary defect in lymphatic tissue as the proximal cause of lipedema is that lymphatic vessel function as determined by lymphangioscintigraphy appears normal in many women with early stages of lipedema and only later can reductions in lymphatic flow rate or function be detected in many women with late stage lipedema (54,63,64)

The search included studies with results available up to June 10, 2025, and was restricted to completed trial records and full-text articles available in English