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Furthermore, the encapsulation of siCD155 in cationic lipid nanoparticles (CLANsiCD155) can effectively deliver siCD155 into infiltrating macrophages and tumor cells, and downregulate CD155 thereby increasing NK cell activation and inhibiting tumor proliferation (85)

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Beyond cell culture systems, the tumor-promoting effects of ROS are validated in models

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Rezamahaleh FA, Khadivzadeh T, Asgharinekah SM, Esmaeili H