lillydirect semaglutide Despite FDA ruling, compounded GLP-1s are still giving Novo and Lilly headaches on the market LillyDirect Semaglutide: Clinical Context &

PLoS Pathog 5(10):e1000639

The average number of treatments is 3 to 4

People were still losing weight when the trial ended, meaning the final number could be even higher with longer use (Lilly Press Release, Dec 2025)

TRPV3 is expressed predominantly in the gastrointestinal tract and skin, with lower expression levels in the muscle, reproductive tissues, brain, and endocrine tissues (TRPV3 protein expression summary - The Human Protein Atlas n.d)

I suspect this is from the glucagon agonism of the drug as glucagon stimulates the formation of extra bile acids/bile salts in the liver which can be very irritating to the intestinal lining causing diarrhea

The front desk ladies were very kind as well