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SPHKAP is expressed in metabolically relevant tissues, including pancreatic islets and intestinal K and L cells, and has been previously shown to play important roles in both incretin secretion from the gut and incretin-dependent glucoregulation 34,35

Hoffman DM, OSullivan AJ, Baxter RC, Ho KK

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Gut microbiome improves postoperative cognitive function by decreasing permeability of the blood-brain barrier in aged mice

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