Simultaneously, it suppresses glucagon secretion from pancreatic alpha cells, which helps prevent excessive glucose production by the liver
A rare but serious adverse effect is lactic acidosis, occurring predominantly in patients with renal impairment, severe dehydration, or acute illness
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These drugs have demonstrated significant clinical efficacy, especially when combined with lifestyle interventions
De novo lipogenesis activity assay Cells were cultured in DMEM with 10% dialyzed FBS and 25 mM [U-C]glucose (Cambridge Isotope Laboratories, 110187-42-3) for 24 h
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